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    • Plasma Proteomics

    Along with blood samples, we collected plasma samples from each subject at each visit, which were interrogated using the Olink Explore 1536 plasma proteomics platform to measure relative abundance of plasma proteins.

    Descriptors of the columns in our olink dataset can be found by clicking the header below:

    Our plasma proteomics dataset contain some sample-level metadata to enable connection between these results and samples used in other modalities. The sample.sampleKitGuid identifier is used across many data modalities.

    Sample Identifiers
    sample.sampleKitGuid: A Globally Unique Identifier (GUID) for the Sample Kit, representing all material collected at a visit
    specimen.specimenGuid: A GUID for the plasma specimen submitted for analysis

    Olink Data (prefix: olink)
    olink.batch_id: Batch submission ID
    olink.plate_id: Plate submission ID
    olink.panel: Olink Panel Name
    olink.assay: Olink Assay Name/Protein Name
    olink.assay_id: Olink Assay ID
    olink.uniprot_id: Uniprot Gene ID
    olink.norm_offset: Offset computed for batch normalization
    olink.NPX_raw: Original NPX value reported by Olink
    olink.NPX_norm: NPX value adjusted by batch normalization
    olink.LOD_raw: Limit of Detection value reported by Olink
    olink.LOD_norm: Limit of Detection value adjusted by batch normalization

    Subject and Sample Metadata (prefix: subject and sample)
    subject.diseaseGroup: Disease status group (e.g. Healthy Control (HC1); At-Risk Individual (ARI))
    subject.progressionGroup: Disease progression group (Converted to RA (CONV) or Non-converter (NONC))
    subject.subjectID: A GUID for the Subject
    subject.diagnosisAge: Age of Subject in years at RA diagnosis (if applicable)
    subject.diagnosisBMI: Body Mass Index of Subject in years at RA diagnosis (if applicable)
    subject.biologicalSex: The biological sex of the Subject
    sample.daysToDiagnosis: Days between sample draw and clinical diagnosis of RA (if applicable)
    sample.daysSinceFirstVisit: Days between initial sample draw and sample collection
    sample.subjectAgeAtDraw: Age of subject at the time of sample collection

    Select Cinical Lab Results (prefix am and infl)
    am.bmi: Anthropometric Measure: Subject Body Mass Index (BMI)
    infl.anti_ccp3: Inflammatory Markers: Anti-CCP3
    infl.rf_iga_result: Inflammatory Markers: RFIgA Result
    infl.rf_igm_result: Inflammatory Markers: RFIgM Result

    ALTRA and Sound Life Olink Data
    File Name Description Download Link
    aifi_altra_sound-life_olink.csv Olink from all samples under study