Plasma Proteomics

Along with blood samples, we collected plasma samples from each subject at each visit, which were interrogated using the Olink Explore 1536 plasma proteomics platform to measure relative abundance of plasma proteins.

Descriptors of the columns in our olink dataset can be found by clicking the header below:

Our plasma proteomics dataset contain some sample-level metadata to enable connection between these results and samples used in other modalities. The sample.sampleKitGuid identifier is used across many data modalities.

Sample Identifiers
sample.sampleKitGuid: A Globally Unique Identifier (GUID) for the Sample Kit, representing all material collected at a visit
specimen.specimenGuid: A GUID for the plasma specimen submitted for analysis

Olink Data (prefix: olink)
olink.batch_id: Batch submission ID
olink.plate_id: Plate submission ID
olink.panel: Olink Panel Name
olink.assay: Olink Assay Name/Protein Name
olink.assay_id: Olink Assay ID
olink.uniprot_id: Uniprot Gene ID
olink.norm_offset: Offset computed for batch normalization
olink.NPX_raw: Original NPX value reported by Olink
olink.NPX_norm: NPX value adjusted by batch normalization
olink.LOD_raw: Limit of Detection value reported by Olink
olink.LOD_norm: Limit of Detection value adjusted by batch normalization

Subject and Sample Metadata (prefix: subject and sample)
subject.diseaseGroup: Disease status group (e.g. Healthy Control (HC1); At-Risk Individual (ARI))
subject.progressionGroup: Disease progression group (Converted to RA (CONV) or Non-converter (NONC))
subject.subjectID: A GUID for the Subject
subject.diagnosisAge: Age of Subject in years at RA diagnosis (if applicable)
subject.diagnosisBMI: Body Mass Index of Subject in years at RA diagnosis (if applicable)
subject.biologicalSex: The biological sex of the Subject
sample.daysToDiagnosis: Days between sample draw and clinical diagnosis of RA (if applicable)
sample.daysSinceFirstVisit: Days between initial sample draw and sample collection
sample.subjectAgeAtDraw: Age of subject at the time of sample collection

Select Cinical Lab Results (prefix am and infl)
am.bmi: Anthropometric Measure: Subject Body Mass Index (BMI)
infl.anti_ccp3: Inflammatory Markers: Anti-CCP3
infl.rf_iga_result: Inflammatory Markers: RFIgA Result
infl.rf_igm_result: Inflammatory Markers: RFIgM Result

ALTRA and Sound Life Olink Data
File Name Description Download Link
aifi_altra_sound-life_olink.csv Olink from all samples under study