The Sound Life Cohort

A collaboration with the Benaroya Research Institute

Lead Collaborators:
Dr. Jane Buckner, Sound Life Primary Investigator
Dr. Cate Speake, Sound Life Project Lead

Data from healthy Young Adult (25 - 35 years old; N = 47) and Older Adult (55 - 65 years old; N = 45) subjects were collected by the Benaroya Research Institute Sound Life Project, in collaboration with Dr. Jane Buckner. Sample collection followed a protocol approved by the institutional review board (IRB) of the Benaroya Research Institute. The Sound Life Cohort consisted of adult donors from the greater Seattle, WA area that were screened to exclude any subjects with a history of chronic or autoimmune disease, chronic infections, or severe allergy.

For more information about the Sound Life Project, see the Benaroya Research Institute Sound Life Project website.

The UPenn Pediatric Cohort

A collaboration with the Children's Hospital of Philadelphia and the University of Pennsylvania

Lead Collaborators:
Dr. E. John Wherry, Primary Investigator
Dr. Sarah Henrickson, Pediatrics Co-Lead
Dr. Laura Vella, Pediatrics Co-Lead

Healthy pediatric donors (11 - 13 years old; N = 16) were recruited from the greater Philadelphia area under a protocol approved by the IRB of the Children’s Hospital of Philadelphia. Donors were excluded from enrollment if they had a history of immune deficiency, fever or antibiotic use within the month before sample collection, chronic medication use, or a body mass index >2 s.d. above or below the mean for their age.

Cohort features

The samples used for this reference dataset consisted of samples derived from 108 healthy subjects across three cohorts.

Below, we show the distribution of number of subjects based on age group, biological sex, and CMV infection status.

Additional subject and sample-level metadata is available on the Downloads page.